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2f31

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{{STRUCTURE_2f31| PDB=2f31 | SCENE= }}
{{STRUCTURE_2f31| PDB=2f31 | SCENE= }}
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'''Crystal structure of the autoinhibitory switch in Formin mDia1; the DID/DAD complex'''
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===Crystal structure of the autoinhibitory switch in Formin mDia1; the DID/DAD complex===
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==Overview==
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Diaphanous-related formins (DRFs) regulate the nucleation and polymerization of unbranched actin filaments. The activity of DRFs is inhibited by an intramolecular interaction between their N-terminal regulatory region and a conserved C-terminal segment termed the Diaphanous autoinhibitory domain (DAD). Binding of GTP bound Rho to the mDia1 N terminus releases this autoinhibitory restraint. Here, we describe the crystal structure of the DAD segment of mDia1 in complex with the relevant N-terminal fragment, termed the DID domain. The structure reveals that the DAD segment forms an amphipathic helix that binds a conserved, concave surface on the DID domain. Comparison with the structure of the mDia1 N terminus bound to RhoC suggests that release of the autoinhibitory DAD interaction is accomplished largely by Rho-induced restructuring of the adjacent GTPase binding subdomain (GBD), but also by electrostatic repulsion and a small, direct steric occlusion of the DAD binding cleft by Rho itself.
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{{ABSTRACT_PUBMED_16472745}}
==About this Structure==
==About this Structure==
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[[Category: Formin,mdia1]]
[[Category: Formin,mdia1]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:24:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:47:21 2008''

Revision as of 09:47, 28 July 2008

Image:2f31.png

Template:STRUCTURE 2f31

Crystal structure of the autoinhibitory switch in Formin mDia1; the DID/DAD complex

Template:ABSTRACT PUBMED 16472745

About this Structure

2F31 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the autoinhibitory switch in formin mDia1., Nezami AG, Poy F, Eck MJ, Structure. 2006 Feb;14(2):257-63. PMID:16472745

Page seeded by OCA on Mon Jul 28 12:47:21 2008

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