2it4
From Proteopedia
(New page: 200px<br /> <applet load="2it4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2it4, resolution 2.0Å" /> '''X ray structure of t...) |
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| - | [[Image:2it4. | + | [[Image:2it4.jpg|left|200px]]<br /><applet load="2it4" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2it4, resolution 2.0Å" /> | caption="2it4, resolution 2.0Å" /> | ||
'''X ray structure of the complex between Carbonic Anhydrase I and the phosphonate antiviral drug foscarnet'''<br /> | '''X ray structure of the complex between Carbonic Anhydrase I and the phosphonate antiviral drug foscarnet'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2IT4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and PPF as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http:// | + | 2IT4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=PPF:'>PPF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IT4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: lyase]] | [[Category: lyase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:39:18 2008'' |
Revision as of 11:39, 23 January 2008
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X ray structure of the complex between Carbonic Anhydrase I and the phosphonate antiviral drug foscarnet
Overview
Foscarnet (phosphonoformate trisodium salt), an antiviral used for the, treatment of HIV and herpes virus infections, also acts as an activator or, inhibitor of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1)., Interaction of the drug with 11 CA isozymes has been investigated, kinetically, and the X-ray structure of its adduct with isoform I (hCA, I-foscarnet complex) has been resolved. The first CA inhibitor possessing, a phosphonate zinc-binding group is thus evidenced, together with the, factors governing recognition of such small molecules by a metalloenzyme, active site. Foscarnet is also a clear-cut example of modulator of an, enzyme activity which can act either as an activator or inhibitor of a CA, isozyme.
About this Structure
2IT4 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Carbonate dehydratase, with EC number 4.2.1.1 Full crystallographic information is available from OCA.
Reference
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I., Temperini C, Innocenti A, Guerri A, Scozzafava A, Rusconi S, Supuran CT, Bioorg Med Chem Lett. 2007 Apr 15;17(8):2210-5. Epub 2007 Feb 8. PMID:17314045
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