2f40

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{{STRUCTURE_2f40| PDB=2f40 | SCENE= }}
{{STRUCTURE_2f40| PDB=2f40 | SCENE= }}
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'''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction'''
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===Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction===
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==Overview==
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Targeting of proteins for structure determination in structural genomic programs often includes the use of threading and fold recognition methods to exclude proteins belonging to well-populated fold families, but such methods can still fail to recognize preexisting folds. The authors illustrate here a method in which limited amounts of structural data are used to improve an initial homology search and the data are subsequently used to produce a structure by data-constrained refinement of an identified structural template. The data used are primarily NMR-based residual dipolar couplings, but they also include additional chemical shift and backbone-nuclear Overhauser effect data. Using this methodology, a backbone structure was efficiently produced for a 10 kDa protein (PF1455) from Pyrococcus furiosus. Its relationship to existing structures and its probable function are discussed.
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{{ABSTRACT_PUBMED_16927360}}
==About this Structure==
==About this Structure==
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2F40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA].
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2F40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA].
==Reference==
==Reference==
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[[Category: Southeast collaboratory for structural genomic]]
[[Category: Southeast collaboratory for structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:26:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:43:16 2008''

Revision as of 12:43, 27 July 2008

Image:2f40.png

Template:STRUCTURE 2f40

Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction

Template:ABSTRACT PUBMED 16927360

About this Structure

2F40 is a Single protein structure of sequence from Pyrococcus furiosus. Full experimental information is available from OCA.

Reference

Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:16927360

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