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2f5u

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{{STRUCTURE_2f5u| PDB=2f5u | SCENE= }}
{{STRUCTURE_2f5u| PDB=2f5u | SCENE= }}
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'''Structural Characterization of the UL25 DNA Packaging Protein from Herpes Simplex Virus Type 1'''
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===Structural Characterization of the UL25 DNA Packaging Protein from Herpes Simplex Virus Type 1===
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==Overview==
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Herpesviruses replicate their double stranded DNA genomes as high-molecular-weight concatemers which are subsequently cleaved into unit-length genomes by a complex mechanism that is tightly coupled to DNA insertion into a preformed capsid structure, the procapsid. The herpes simplex virus type 1 UL25 protein is incorporated into the capsid during DNA packaging, and previous studies of a null mutant have demonstrated that its function is essential at the late stages of the head-filling process, either to allow packaging to proceed to completion or for retention of the viral genome within the capsid. We have expressed and purified an N-terminally truncated form of the 580-residue UL25 protein and have determined the crystallographic structure of the region corresponding to amino acids 134 to 580 at 2.1-Angstroms resolution. This structure, the first for any herpesvirus protein involved in processing and packaging of viral DNA, reveals a novel fold, a distinctive electrostatic distribution, and a unique "flexible" architecture in which numerous flexible loops emanate from a stable core. Evolutionary trace analysis of UL25 and its homologues in other herpesviruses was used to locate potentially important amino acids on the surface of the protein, leading to the identification of four putative docking regions for protein partners.
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(as it appears on PubMed at http://www.pubmed.gov), where 16474137 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16474137}}
==About this Structure==
==About this Structure==
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[[Category: Hsv-1]]
[[Category: Hsv-1]]
[[Category: Ul25]]
[[Category: Ul25]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:29:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:55:53 2008''

Revision as of 10:55, 27 July 2008

Image:2f5u.png

Template:STRUCTURE 2f5u

Structural Characterization of the UL25 DNA Packaging Protein from Herpes Simplex Virus Type 1

Template:ABSTRACT PUBMED 16474137

About this Structure

2F5U is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Structural characterization of the UL25 DNA-packaging protein from herpes simplex virus type 1., Bowman BR, Welschhans RL, Jayaram H, Stow ND, Preston VG, Quiocho FA, J Virol. 2006 Mar;80(5):2309-17. PMID:16474137

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