2f68

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[[Image:2f68.gif|left|200px]]
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{{STRUCTURE_2f68| PDB=2f68 | SCENE= }}
{{STRUCTURE_2f68| PDB=2f68 | SCENE= }}
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'''Crystal structure of collagen adhesin (CNA) from S. aureus'''
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===Crystal structure of collagen adhesin (CNA) from S. aureus===
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==Overview==
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The structural basis for the association of eukaryotic and prokaryotic protein receptors and their triple-helical collagen ligand remains poorly understood. Here, we present the crystal structures of a high affinity subsegment of the Staphylococcus aureus collagen-binding CNA as an apo-protein and in complex with a synthetic collagen-like triple helical peptide. The apo-protein structure is composed of two subdomains (N1 and N2), each adopting a variant IgG-fold, and a long linker that connects N1 and N2. The structure is stabilized by hydrophobic inter-domain interactions and by the N2 C-terminal extension that complements a beta-sheet on N1. In the ligand complex, the collagen-like peptide penetrates through a spherical hole formed by the two subdomains and the N1-N2 linker. Based on these two structures we propose a dynamic, multistep binding model, called the 'Collagen Hug' that is uniquely designed to allow multidomain collagen binding proteins to bind their extended rope-like ligand.
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(as it appears on PubMed at http://www.pubmed.gov), where 16362049 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16362049}}
==About this Structure==
==About this Structure==
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Domain swap]]
[[Category: Domain swap]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:30:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:36:01 2008''

Revision as of 09:36, 27 July 2008

Image:2f68.png

Template:STRUCTURE 2f68

Crystal structure of collagen adhesin (CNA) from S. aureus

Template:ABSTRACT PUBMED 16362049

About this Structure

2F68 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen., Zong Y, Xu Y, Liang X, Keene DR, Hook A, Gurusiddappa S, Hook M, Narayana SV, EMBO J. 2005 Dec 21;24(24):4224-36. Epub 2005 Dec 15. PMID:16362049

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