2f70

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[[Image:2f70.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2f70| PDB=2f70 | SCENE= }}
{{STRUCTURE_2f70| PDB=2f70 | SCENE= }}
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'''Protein tyrosine phosphatase 1B with sulfamic acid inhibitors'''
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===Protein tyrosine phosphatase 1B with sulfamic acid inhibitors===
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==Overview==
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High-throughput screening of the P&amp;GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
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(as it appears on PubMed at http://www.pubmed.gov), where 16386905 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16386905}}
==About this Structure==
==About this Structure==
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[[Category: Tetrahydroisoquinoline]]
[[Category: Tetrahydroisoquinoline]]
[[Category: Tyrosine]]
[[Category: Tyrosine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:32:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:10:40 2008''

Revision as of 16:10, 28 July 2008

Template:STRUCTURE 2f70

Protein tyrosine phosphatase 1B with sulfamic acid inhibitors

Template:ABSTRACT PUBMED 16386905

About this Structure

2F70 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors., Klopfenstein SR, Evdokimov AG, Colson AO, Fairweather NT, Neuman JJ, Maier MB, Gray JL, Gerwe GS, Stake GE, Howard BW, Farmer JA, Pokross ME, Downs TR, Kasibhatla B, Peters KG, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1574-8. Epub 2006 Jan 4. PMID:16386905

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