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2f83

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[[Image:2f83.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2f83| PDB=2f83 | SCENE= }}
{{STRUCTURE_2f83| PDB=2f83 | SCENE= }}
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'''Crystal structure of a human coagulation factor'''
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===Crystal structure of a human coagulation factor===
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==Overview==
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Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI zymogen crystal structure, revealing that the protease and four apple domains assemble into a unique 'cup and saucer' architecture. The structure shows that the thrombin and platelet glycoprotein Ib binding sites are remote within the monomer but lie in close proximity across the dimer, suggesting a transactivation mechanism.
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The line below this paragraph, {{ABSTRACT_PUBMED_16699514}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16699514 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16699514}}
==About this Structure==
==About this Structure==
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[[Category: Apple domain]]
[[Category: Apple domain]]
[[Category: Protease]]
[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:34:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:54:38 2008''

Revision as of 04:54, 28 July 2008

Image:2f83.png

Template:STRUCTURE 2f83

Crystal structure of a human coagulation factor

Template:ABSTRACT PUBMED 16699514

About this Structure

2F83 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the factor XI zymogen reveals a pathway for transactivation., Papagrigoriou E, McEwan PA, Walsh PN, Emsley J, Nat Struct Mol Biol. 2006 Jun;13(6):557-8. Epub 2006 May 14. PMID:16699514

Page seeded by OCA on Mon Jul 28 07:54:38 2008

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