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2f86

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{{STRUCTURE_2f86| PDB=2f86 | SCENE= }}
{{STRUCTURE_2f86| PDB=2f86 | SCENE= }}
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'''The Association Domain of C. elegans CaMKII'''
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===The Association Domain of C. elegans CaMKII===
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==Overview==
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Ca2+/calmodulin activated protein kinase II (CaMKII) is an oligomeric protein kinase with a unique holoenyzme architecture. The subunits of CaMKII are bound together into the holoenzyme by the association domain, a C-terminal region of approximately 140 residues in the CaMKII polypeptide. Single particle analyses of electron micrographs have suggested previously that the holoenyzme forms a dodecamer that contains two stacked 6-fold symmetric rings. In contrast, a recent crystal structure of the isolated association domain of mouse CaMKIIalpha has revealed a tetradecameric assembly with two stacked 7-fold symmetric rings. In this study, we have determined the crystal structure of the Caenorhabditis elegans CaMKII association domain and it too forms a tetradecamer. We also show by electron microscopy that in its fully assembled form the CaMKII holoenzyme is a dodecamer but without the kinase domains, either from expression of the isolated association domain in bacteria or following their removal by proteolysis, the association domains form a tetradecamer. We speculate that the holoenzyme is held in its 6-fold symmetric state by the interactions of the N-terminal approximately 1-335 residues and that the removal of this region allows the association domain to convert into a more stable 7-fold symmetric form.
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(as it appears on PubMed at http://www.pubmed.gov), where 16441656 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16441656}}
==About this Structure==
==About this Structure==
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[[Category: Oligomerization domain]]
[[Category: Oligomerization domain]]
[[Category: Unc-43]]
[[Category: Unc-43]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:34:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:01:27 2008''

Revision as of 15:01, 27 July 2008

Image:2f86.png

Template:STRUCTURE 2f86

The Association Domain of C. elegans CaMKII

Template:ABSTRACT PUBMED 16441656

About this Structure

2F86 is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II., Rosenberg OS, Deindl S, Comolli LR, Hoelz A, Downing KH, Nairn AC, Kuriyan J, FEBS J. 2006 Feb;273(4):682-94. PMID:16441656

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