This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.




2fcp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2fcp.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2fcp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2fcp| PDB=2fcp | SCENE= }}
{{STRUCTURE_2fcp| PDB=2fcp | SCENE= }}
-
'''FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI'''
+
===FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI===
-
==Overview==
+
<!--
-
FhuA, the receptor for ferrichrome-iron in Escherichia coli, is a member of a family of integral outer membrane proteins, which, together with the energy-transducing protein TonB, mediate the active transport of ferric siderophores across the outer membrane of Gram-negative bacteria. The three-dimensional structure of FhuA is presented here in two conformations: with and without ferrichrome-iron at resolutions of 2.7 and 2.5 angstroms, respectively. FhuA is a beta barrel composed of 22 antiparallel beta strands. In contrast to the typical trimeric arrangement found in porins, FhuA is monomeric. Located within the beta barrel is a structurally distinct domain, the "cork," which mainly consists of a four-stranded beta sheet and four short alpha helices. A single lipopolysaccharide molecule is noncovalently associated with the membrane-embedded region of the protein. Upon binding of ferrichrome-iron, conformational changes are transduced to the periplasmic pocket of FhuA, signaling the ligand-loaded status of the receptor. Sequence homologies and mutagenesis data are used to propose a structural mechanism for TonB-dependent siderophore-mediated transport across the outer membrane.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9856937}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9856937 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9856937}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Iron transport protein]]
[[Category: Iron transport protein]]
[[Category: Tonb-dependent receptor]]
[[Category: Tonb-dependent receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:44:22 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:26:56 2008''

Revision as of 03:26, 29 July 2008

Image:2fcp.png

Template:STRUCTURE 2fcp

FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI

Template:ABSTRACT PUBMED 9856937

About this Structure

2FCP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide., Ferguson AD, Hofmann E, Coulton JW, Diederichs K, Welte W, Science. 1998 Dec 18;282(5397):2215-20. PMID:9856937

Page seeded by OCA on Tue Jul 29 06:26:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fcp"
Personal tools