2j50
From Proteopedia
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| - | [[Image:2j50. | + | [[Image:2j50.jpg|left|200px]]<br /><applet load="2j50" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2j50" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2j50, resolution 3.00Å" /> | caption="2j50, resolution 3.00Å" /> | ||
'''STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358'''<br /> | '''STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2J50 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and 627 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | + | 2J50 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and 627 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J50 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:49:11 2007'' |
Revision as of 17:39, 18 December 2007
|
STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358
Contents |
Overview
The optimization of a series of 5-phenylacetyl, 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives toward the inhibition, of Aurora kinases led to the identification of compound 9d. This is a, potent inhibitor of Aurora kinases that also shows low nanomolar potency, against additional anticancer kinase targets. Based on its high, antiproliferative activity on different cancer cell lines, favorable, chemico-physical and pharmacokinetic properties, and high efficacy in in, vivo tumor models, compound 9d was ultimately selected for further, development.
Disease
Known diseases associated with this structure: Colon cancer, susceptibility to OMIM:[603072]
About this Structure
2J50 is a Single protein structure of sequence from Homo sapiens with SO4 and 627 as ligands. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile., Fancelli D, Moll J, Varasi M, Bravo R, Artico R, Berta D, Bindi S, Cameron A, Candiani I, Cappella P, Carpinelli P, Croci W, Forte B, Giorgini ML, Klapwijk J, Marsiglio A, Pesenti E, Rocchetti M, Roletto F, Severino D, Soncini C, Storici P, Tonani R, Zugnoni P, Vianello P, J Med Chem. 2006 Nov 30;49(24):7247-51. PMID:17125279
Page seeded by OCA on Tue Dec 18 19:49:11 2007
Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Single protein | Berta, D. | Bindi, S. | Cameron, A.D. | Fancelli, D. | Forte, B. | Izzo, G. | Rusconi, L. | Severino, D. | Storici, P. | Tonani, R. | Varasi, M. | Vianello, P. | 627 | SO4 | Atp-binding | Cell cycle | Kinase | Nucleotide- binding | Nucleotide-binding | Phosphorylation | Serine-threonine-protein kinase | Serine/threonine-protein kinase | Transferase
