2fei

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[[Image:2fei.jpg|left|200px]]
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{{STRUCTURE_2fei| PDB=2fei | SCENE= }}
{{STRUCTURE_2fei| PDB=2fei | SCENE= }}
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'''Solution structure of the second SH3 domain of Human CMS protein'''
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===Solution structure of the second SH3 domain of Human CMS protein===
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==Overview==
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CMS, cas ligand with multiple Src homology 3 (SH3) domains, belongs to a family of ubiquitously expressed adaptor proteins. Among the CMS binding proteins, c-Cbl has been mostly extensively studied. It was reported that the motif PKPFPR (residues 824-829) of c-Cbl can bind to the N-terminus SH3 domains of CMS. Here we report the solution structure of the second SH3 domain of CMS (CMS_SH3_B), furthermore, we have identified that a peptide from residues 701 to 714 of c-Cbl (Cbl-p), i.e. MTPSSRPLRPLDTS, can specially bind to CMS_SH3_B using NMR chemical shift perturbation, suggesting that the peptide is a new potential CMS binding site. Among the peptide, TPSSRPLR is the core binding motif and Arg709 plays a key role in the interaction. Cbl-p binding interface on CMS_SH3_B along a hydrophobic channel is composed of RT loop, n-Src loop and beta4 strand and divided into three pockets. This work indicates the solution structure of CMS_SH3_B bears the canonical beta-beta-beta-beta-alpha-beta fold and a new binding site in c-Cbl involved in its interaction with CMS, which probably contributes to the clustering of CMS. All the information provided here should be beneficial for the future functional study of CMS.
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The line below this paragraph, {{ABSTRACT_PUBMED_17188587}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17188587 is the PubMed ID number.
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==Disease==
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Known disease associated with this structure: Glomerulosclerosis, focal segmental, 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604241 604241]]
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{{ABSTRACT_PUBMED_17188587}}
==About this Structure==
==About this Structure==
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2FEI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEI OCA].
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2FEI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEI OCA].
==Reference==
==Reference==
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[[Category: Yao, B.]]
[[Category: Yao, B.]]
[[Category: Cms sh3 domain]]
[[Category: Cms sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:48:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:17:15 2008''

Revision as of 10:17, 28 July 2008

Image:2fei.png

Template:STRUCTURE 2fei

Solution structure of the second SH3 domain of Human CMS protein

Template:ABSTRACT PUBMED 17188587

About this Structure

2FEI is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the second SH3 domain of human CMS and a newly identified binding site at the C-terminus of c-Cbl., Yao B, Zhang J, Dai H, Sun J, Jiao Y, Tang Y, Wu J, Shi Y, Biochim Biophys Acta. 2007 Jan;1774(1):35-43. Epub 2006 Oct 27. PMID:17188587

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