2fic

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{{STRUCTURE_2fic| PDB=2fic | SCENE= }}
{{STRUCTURE_2fic| PDB=2fic | SCENE= }}
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'''The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition'''
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===The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition===
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==Overview==
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BAR domains are found in proteins that bind and remodel membranes and participate in cytoskeletal and nuclear processes. Here, we report the crystal structure of the BAR domain from the human Bin1 protein at 2.0 A resolution. Both the quaternary and tertiary architectures of the homodimeric Bin1BAR domain are built upon "knobs-into-holes" packing of side chains, like those found in conventional left-handed coiled-coils, and this packing governs the curvature of a putative membrane-engaging concave face. Our calculations indicate that the Bin1BAR domain contains two potential sites for protein-protein interactions on the convex face of the dimer. Comparative analysis of structural features reveals that at least three architectural subtypes of the BAR domain are encoded in the human genome, represented by the Arfaptin, Bin1/Amphiphysin, and IRSp53 BAR domains. We discuss how these principal groups may differ in their potential to form regulatory heterotypic interactions.
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==About this Structure==
==About this Structure==
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[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
[[Category: Homodimer]]
[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:55:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:47:18 2008''

Revision as of 02:47, 28 July 2008

Image:2fic.png

Template:STRUCTURE 2fic

The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition

Template:ABSTRACT PUBMED 17059209

About this Structure

2FIC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition., Casal E, Federici L, Zhang W, Fernandez-Recio J, Priego EM, Miguel RN, DuHadaway JB, Prendergast GC, Luisi BF, Laue ED, Biochemistry. 2006 Oct 31;45(43):12917-28. PMID:17059209

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