This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2fif

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2fif.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2fif.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2fif| PDB=2fif | SCENE= }}
{{STRUCTURE_2fif| PDB=2fif | SCENE= }}
-
'''Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin'''
+
===Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin===
-
==Overview==
+
<!--
-
Rabex-5 is an exchange factor for Rab5, a master regulator of endosomal trafficking. Rabex-5 binds monoubiquitin, undergoes covalent ubiquitination and contains an intrinsic ubiquitin ligase activity, all of which require an N-terminal A20 zinc finger followed immediately by a helix. The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites. The first site is a new type of ubiquitin-binding domain, an inverted ubiquitin-interacting motif, which binds with approximately 29-microM affinity to the canonical Ile44 hydrophobic patch on ubiquitin. The second is a diaromatic patch on the A20 zinc finger, which binds with approximately 22-microM affinity to a polar region centered on Asp58 of ubiquitin. The A20 zinc-finger diaromatic patch mediates ubiquitin-ligase activity by directly recruiting a ubiquitin-loaded ubiquitin-conjugating enzyme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16462746}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16462746 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16462746}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Helix]]
[[Category: Helix]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:56:09 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:03:41 2008''

Revision as of 19:03, 28 July 2008

Image:2fif.png

Template:STRUCTURE 2fif

Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin

Template:ABSTRACT PUBMED 16462746

About this Structure

2FIF is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5., Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Mar;13(3):264-71. Epub 2006 Feb 5. PMID:16462746

Page seeded by OCA on Mon Jul 28 22:03:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fif"
Personal tools