2fih

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{{STRUCTURE_2fih| PDB=2fih | SCENE= }}
{{STRUCTURE_2fih| PDB=2fih | SCENE= }}
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'''Crystal Structure Analysis of the B-DNA Dodecamer CGCGAA-aU-TCGCG, with Incorporated Arabino-Uridine (aU)'''
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===Crystal Structure Analysis of the B-DNA Dodecamer CGCGAA-aU-TCGCG, with Incorporated Arabino-Uridine (aU)===
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==Overview==
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2'-Deoxy-2'-fluoro-arabinonucleic acid (FANA) and arabinonucleic acid (ANA) paired to RNA are substrates of RNase H. The conformation of the natural DNA/RNA hybrid substrates appears to be neither A-form nor B-form. Consistent with this, the conformations of FANA and ANA were found to be intermediate between the A- and B-forms. However, FANA opposite RNA is preferred by RNase H over ANA, and the RNA affinity of FANA considerably exceeds that of ANA. By investigating the conformational boundaries of FANA and ANA residues in crystal structures of A- and B-form DNA duplexes at atomic resolution, we demonstrate that FANA and ANA display subtle conformational differences. The structural data provide insight into the structural requirements at the catalytic site of RNase H. They also allow conclusions with regard to the relative importance of stereoelectronic effects and hydration as modulators of RNA affinity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16566588 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16566588}}
==About this Structure==
==About this Structure==
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[[Category: B-form dna]]
[[Category: B-form dna]]
[[Category: Sugar modification]]
[[Category: Sugar modification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:56:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:37:46 2008''

Revision as of 04:37, 28 July 2008

Image:2fih.png

Template:STRUCTURE 2fih

Crystal Structure Analysis of the B-DNA Dodecamer CGCGAA-aU-TCGCG, with Incorporated Arabino-Uridine (aU)

Template:ABSTRACT PUBMED 16566588

About this Structure

Full crystallographic information is available from OCA.

Reference

2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H., Li F, Sarkhel S, Wilds CJ, Wawrzak Z, Prakash TP, Manoharan M, Egli M, Biochemistry. 2006 Apr 4;45(13):4141-52. PMID:16566588

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