2c4r

From Proteopedia

Revision as of 10:11, 30 October 2007

CATALYTIC DOMAIN OF E. COLI RNASE E

Overview

The coordinated regulation of gene expression is required for homeostasis, growth and development in all organisms. Such coordination may be partly, achieved at the level of messenger RNA stability, in which the targeted, destruction of subsets of transcripts generates the potential for, cross-regulating metabolic pathways. In Escherichia coli, the balance and, composition of the transcript population is affected by RNase E, an, essential endoribonuclease that not only turns over RNA but also processes, certain key RNA precursors. RNase E cleaves RNA internally, but its, catalytic power is determined by the 5' terminus of the substrate, even if, this lies at a distance from the cutting site. Here we report crystal, structures of the catalytic domain of RNase E as trapped allosteric, ... [(full description)]

About this Structure

2C4R is a [Single protein] structure of sequence from [Escherichia coli] with MG and ZN as [ligands]. Structure known Active Site: AC2. Full crystallographic information is available from [OCA].

Reference

Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover., Callaghan AJ, Marcaida MJ, Stead JA, McDowall KJ, Scott WG, Luisi BF, Nature. 2005 Oct 20;437(7062):1187-91. PMID:16237448

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