2fju

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{{STRUCTURE_2fju| PDB=2fju | SCENE= }}
{{STRUCTURE_2fju| PDB=2fju | SCENE= }}
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'''Activated Rac1 bound to its effector phospholipase C beta 2'''
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===Activated Rac1 bound to its effector phospholipase C beta 2===
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==Overview==
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Although diverse signaling cascades require the coordinated regulation of heterotrimeric G proteins and small GTPases, these connections remain poorly understood. We present the crystal structure of the GTPase Rac1 bound to phospholipase C-beta2 (PLC-beta2), a classic effector of heterotrimeric G proteins. Rac1 engages the pleckstrin-homology (PH) domain of PLC-beta2 to optimize its orientation for substrate membranes. Gbetagamma also engages the PH domain to activate PLC-beta2, and these two activation events are compatible, leading to additive stimulation of phospholipase activity. In contrast to PLC-delta, the PH domain of PLC-beta2 cannot bind phosphoinositides, eliminating this mode of regulation. The structure of the Rac1-PLC-beta2 complex reveals determinants that dictate selectivity of PLC-beta isozymes for Rac GTPases over other Rho-family GTPases, and substitutions within PLC-beta2 abrogate its stimulation by Rac1 but not by Gbetagamma, allowing for functional dissection of this integral signaling node.
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{{ABSTRACT_PUBMED_17115053}}
==Disease==
==Disease==
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[[Category: Sondek, J.]]
[[Category: Sondek, J.]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:58:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:28:49 2008''

Revision as of 03:28, 28 July 2008

Image:2fju.png

Template:STRUCTURE 2fju

Contents

Activated Rac1 bound to its effector phospholipase C beta 2

Template:ABSTRACT PUBMED 17115053

Disease

Known disease associated with this structure: Platelet PLC beta-2 deficiency OMIM:[604114]

About this Structure

2FJU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Rac1 bound to its effector phospholipase C-beta2., Jezyk MR, Snyder JT, Gershberg S, Worthylake DK, Harden TK, Sondek J, Nat Struct Mol Biol. 2006 Dec;13(12):1135-40. Epub 2006 Nov 19. PMID:17115053

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