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2fjy

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[[Image:2fjy.gif|left|200px]]
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{{Seed}}
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[[Image:2fjy.png|left|200px]]
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{{STRUCTURE_2fjy| PDB=2fjy | SCENE= }}
{{STRUCTURE_2fjy| PDB=2fjy | SCENE= }}
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'''Crystal Structure of B-form Bombyx mori Pheromone Binding Protein'''
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===Crystal Structure of B-form Bombyx mori Pheromone Binding Protein===
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==Overview==
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The transport of hydrophobic insect pheromones through the aqueous medium surrounding their receptors is assisted by pheromone-binding proteins (PBPs). The protein from the silkworm moth Bombyx mori, BmorPBP, exhibits a pH-dependent conformational change postulated to trigger the release of the pheromone bombykol to its receptor. At low pH, an alpha-helix occupies the same binding pocket that houses the pheromone in the BmorPBP-bombykol complex at high pH. We have determined the crystal structure of apo BmorPBP at a resolution of 2.3 angstroms and pH 7.5, which has surprisingly a structure similar to the A-form. These data suggest that BmorPBP undergoes a ligand-dependent conformational change in addition to the previously described pH-dependent conformational change. Analysis of the alpha-helix occupying the binding pocket reveals an amphipathic helix with three acidic residues along one face that are conserved among lepidopteran PBPs and may be involved in a conformational transition of BmorPBP at the receptor membrane.
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The line below this paragraph, {{ABSTRACT_PUBMED_16111659}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16111659 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16111659}}
==About this Structure==
==About this Structure==
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[[Category: Leal, W S.]]
[[Category: Leal, W S.]]
[[Category: Alpha helical]]
[[Category: Alpha helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:59:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:36:15 2008''

Revision as of 06:36, 28 July 2008

Image:2fjy.png

Template:STRUCTURE 2fjy

Crystal Structure of B-form Bombyx mori Pheromone Binding Protein

Template:ABSTRACT PUBMED 16111659

About this Structure

2FJY is a Single protein structure of sequence from Bombyx mori. Full crystallographic information is available from OCA.

Reference

Coil-to-helix transition and ligand release of Bombyx mori pheromone-binding protein., Lautenschlager C, Leal WS, Clardy J, Biochem Biophys Res Commun. 2005 Oct 7;335(4):1044-50. PMID:16111659

Page seeded by OCA on Mon Jul 28 09:36:15 2008

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