2fk0

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[[Image:2fk0.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2fk0| PDB=2fk0 | SCENE= }}
{{STRUCTURE_2fk0| PDB=2fk0 | SCENE= }}
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'''Crystal Structure of a H5N1 influenza virus hemagglutinin.'''
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===Crystal Structure of a H5N1 influenza virus hemagglutinin.===
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==Overview==
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The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human alpha2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population.
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The line below this paragraph, {{ABSTRACT_PUBMED_16543414}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16543414 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16543414}}
==About this Structure==
==About this Structure==
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[[Category: Membrane-fusion precursor]]
[[Category: Membrane-fusion precursor]]
[[Category: Virus/viral protein]]
[[Category: Virus/viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:59:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:51:50 2008''

Revision as of 23:51, 27 July 2008

Image:2fk0.png

Template:STRUCTURE 2fk0

Crystal Structure of a H5N1 influenza virus hemagglutinin.

Template:ABSTRACT PUBMED 16543414

About this Structure

2FK0 is a Protein complex structure of sequences from Viruses. Full crystallographic information is available from OCA.

Reference

Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:16543414

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