2fk9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2fk9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2fk9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2fk9| PDB=2fk9 | SCENE= }}
{{STRUCTURE_2fk9| PDB=2fk9 | SCENE= }}
-
'''Human protein kinase C, eta'''
+
===Human protein kinase C, eta===
-
==Overview==
+
<!--
-
Protein kinase C eta (PKCeta) is one of several PKC isoforms found in humans. It is a novel PKC isoform in that it is activated by diacylglycerol and anionic phospholipids but not calcium. The crystal structure of the PKCeta-C2 domain, which is thought to mediate anionic phospholipid sensing in the protein, was determined at 1.75 A resolution. The structure is similar to that of the PKC epsilon C2 domain but with significant variations at the putative lipid-binding site. Two serine residues within PKC eta were identified in vitro as potential autophosphorylation sites. In the unphosphorylated structure both serines line the putative lipid-binding site and may therefore play a role in the lipid-regulation of the kinase.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16973127}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16973127 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16973127}}
==Disease==
==Disease==
Line 48: Line 52:
[[Category: Structural genomics consortium]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:59:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:29:48 2008''

Revision as of 09:29, 27 July 2008

Image:2fk9.png

Template:STRUCTURE 2fk9

Contents

Human protein kinase C, eta

Template:ABSTRACT PUBMED 16973127

Disease

Known disease associated with this structure: Cerebral infarction, susceptibility to OMIM:[605437]

About this Structure

2FK9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites., Littler DR, Walker JR, She YM, Finerty PJ Jr, Newman EM, Dhe-Paganon S, Biochem Biophys Res Commun. 2006 Nov 3;349(4):1182-9. Epub 2006 Sep 5. PMID:16973127

Page seeded by OCA on Sun Jul 27 12:29:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fk9"
Personal tools