2fmd

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[[Image:2fmd.gif|left|200px]]
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{{Seed}}
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[[Image:2fmd.png|left|200px]]
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{{STRUCTURE_2fmd| PDB=2fmd | SCENE= }}
{{STRUCTURE_2fmd| PDB=2fmd | SCENE= }}
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'''Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin'''
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===Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin===
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==Overview==
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The crystal structure of the seed lectin from the tropical legume Bowringia milbraedii was determined in complex with the disaccharide ligand Man(alpha1-2)Man. In solution, the protein exhibits a dynamic dimer-tetramer equilibrium, consistent with the concanavalin A-type tetramer observed in the crystal. Contacts between the tetramers are mediated almost exclusively through the carbohydrate ligand, resulting in a crystal lattice virtually identical to that of the concanavalin-A:Man(alpha1-2)Man complex, even though both proteins have less than 50% sequence identity. The disaccharide binds exclusively in a "downstream" binding mode, with the non-reducing mannose occupying the monosaccharide-binding site. The reducing mannose is bound in a predominantly polar subsite involving Tyr131, Gln218, and Tyr219.
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The line below this paragraph, {{ABSTRACT_PUBMED_16567368}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16567368 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16567368}}
==About this Structure==
==About this Structure==
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[[Category: Legume lectin]]
[[Category: Legume lectin]]
[[Category: Protein-carbohydrate complex]]
[[Category: Protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:04:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:53:00 2008''

Revision as of 09:53, 28 July 2008

Image:2fmd.png

Template:STRUCTURE 2fmd

Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin

Template:ABSTRACT PUBMED 16567368

About this Structure

2FMD is a Single protein structure of sequence from Bowringia mildbraedii. Full crystallographic information is available from OCA.

Reference

Structural basis of carbohydrate recognition by a Man(alpha1-2)Man-specific lectin from Bowringia milbraedii., Buts L, Garcia-Pino A, Wyns L, Loris R, Glycobiology. 2006 Jul;16(7):635-40. Epub 2006 Mar 27. PMID:16567368

Page seeded by OCA on Mon Jul 28 12:53:00 2008

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