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2fmt

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[[Image:2fmt.gif|left|200px]]
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{{STRUCTURE_2fmt| PDB=2fmt | SCENE= }}
{{STRUCTURE_2fmt| PDB=2fmt | SCENE= }}
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'''METHIONYL-TRNAFMET FORMYLTRANSFERASE COMPLEXED WITH FORMYL-METHIONYL-TRNAFMET'''
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===METHIONYL-TRNAFMET FORMYLTRANSFERASE COMPLEXED WITH FORMYL-METHIONYL-TRNAFMET===
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==Overview==
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The crystal structure of Escherichia coli methionyl-tRNAfMet transformylase complexed with formyl-methionyl-tRNAfMet was solved at 2.8 A resolution. The formylation reaction catalyzed by this enzyme irreversibly commits methionyl-tRNAfMet to initiation of translation in eubacteria. In the three-dimensional model, the methionyl-tRNAfMet formyltransferase fills in the inside of the L-shaped tRNA molecule on the D-stem side. The anticodon stem and loop are away from the protein. An enzyme loop is wedged in the major groove of the acceptor helix. As a result, the C1-A72 mismatch characteristic of the initiator tRNA is split and the 3' arm bends inside the active centre. This recognition mechanism is markedly distinct from that of elongation factor Tu, which binds the acceptor arm of aminoacylated elongator tRNAs on the T-stem side.
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(as it appears on PubMed at http://www.pubmed.gov), where 9843487 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9843487}}
==About this Structure==
==About this Structure==
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[[Category: Formyltransferase]]
[[Category: Formyltransferase]]
[[Category: Initiation of translation]]
[[Category: Initiation of translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:04:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:27:49 2008''

Revision as of 10:27, 29 July 2008

Image:2fmt.png

Template:STRUCTURE 2fmt

METHIONYL-TRNAFMET FORMYLTRANSFERASE COMPLEXED WITH FORMYL-METHIONYL-TRNAFMET

Template:ABSTRACT PUBMED 9843487

About this Structure

2FMT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet., Schmitt E, Panvert M, Blanquet S, Mechulam Y, EMBO J. 1998 Dec 1;17(23):6819-26. PMID:9843487

Page seeded by OCA on Tue Jul 29 13:27:49 2008

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