2fmx

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{{STRUCTURE_2fmx| PDB=2fmx | SCENE= }}
{{STRUCTURE_2fmx| PDB=2fmx | SCENE= }}
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'''An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)'''
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===An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)===
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==Overview==
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Mg2+ is essential for guanosine triphosphatase activity and plays key roles in guanine nucleotide binding and preserving the structural integrity of GTP-binding proteins. To understand the structural basis for Mg2+ function during the GDP/GTP exchange process, we determined the crystal structure of Delta9-Sar1-GDP at low Mg2+ concentration at 1.8A. Two Sar1-GDP molecules in the crystal form a dimer with Mg2+ presenting only in molecule B but not in molecule A. The absence of Mg2+ induces significant conformational changes in the switch I region in molecule A that shows similarities with those of Ha-Ras bound to Sos. The current structure reveals an important regulatory role for Mg2+. We suggest that guanine nucleotide exchange factor may utilize this feature to generate an open conformation for GDP/GTP exchange. Furthermore, we propose a mechanism for COPII assembly and disassembly in which dimerization of Sar1 plays an important role.
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{{ABSTRACT_PUBMED_16899220}}
==About this Structure==
==About this Structure==
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[[Category: Dimerization]]
[[Category: Dimerization]]
[[Category: Sar1]]
[[Category: Sar1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:05:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:51:52 2008''

Revision as of 11:51, 27 July 2008

Image:2fmx.png

Template:STRUCTURE 2fmx

An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)

Template:ABSTRACT PUBMED 16899220

About this Structure

2FMX is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg2+., Rao Y, Bian C, Yuan C, Li Y, Chen L, Ye X, Huang Z, Huang M, Biochem Biophys Res Commun. 2006 Sep 29;348(3):908-15. Epub 2006 Aug 1. PMID:16899220

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