2xbd
From Proteopedia
(New page: 200px<br /> <applet load="2xbd" size="450" color="white" frame="true" align="right" spinBox="true" caption="2xbd" /> '''INTERNAL XYLAN BINDING DOMAIN FROM CELLULOM...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2XBD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Cellulomonas_fimi Cellulomonas fimi]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2XBD OCA]]. | + | 2XBD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Cellulomonas_fimi Cellulomonas fimi]]. Active as [[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8]]. Structure known Active Site: XBD. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2XBD OCA]]. |
==Reference== | ==Reference== | ||
A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity., Simpson PJ, Bolam DN, Cooper A, Ciruela A, Hazlewood GP, Gilbert HJ, Williamson MP, Structure. 1999 Jul 15;7(7):853-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10425686 10425686] | A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity., Simpson PJ, Bolam DN, Cooper A, Ciruela A, Hazlewood GP, Gilbert HJ, Williamson MP, Structure. 1999 Jul 15;7(7):853-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10425686 10425686] | ||
[[Category: Cellulomonas fimi]] | [[Category: Cellulomonas fimi]] | ||
| + | [[Category: Endo-1,4-beta-xylanase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bolam, D.N.]] | [[Category: Bolam, D.N.]] | ||
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[[Category: xylanase]] | [[Category: xylanase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:16:01 2007'' |
Revision as of 10:11, 30 October 2007
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INTERNAL XYLAN BINDING DOMAIN FROM CELLULOMONAS FIMI XYLANASE D, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
BACKGROUND: Many enzymes that digest polysaccharides contain separate, polysaccharide-binding domains. Structures have been previously determined, for a number of cellulose-binding domains (CBDs) from cellulases. RESULTS:, The family IIb xylan-binding domain 1 (XBD1) from Cellulomonas fimi, xylanase D is shown to bind xylan but not cellulose. Its structure is, similar to that of the homologous family IIa CBD from C. fimi Cex, consisting of two four-stranded beta sheets that form a twisted 'beta, sandwich'. The xylan-binding site is a groove made from two tryptophan, residues that stack against the faces of the sugar rings, plus several, hydrogen-bonding polar residues. CONCLUSIONS: The biggest difference, between the family IIa and IIb domains is that in the former the, solvent-exposed ... [(full description)]
About this Structure
2XBD is a [Single protein] structure of sequence from [Cellulomonas fimi]. Active as [Endo-1,4-beta-xylanase], with EC number [3.2.1.8]. Structure known Active Site: XBD. Full crystallographic information is available from [OCA].
Reference
A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity., Simpson PJ, Bolam DN, Cooper A, Ciruela A, Hazlewood GP, Gilbert HJ, Williamson MP, Structure. 1999 Jul 15;7(7):853-64. PMID:10425686
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