2fo0

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{{STRUCTURE_2fo0| PDB=2fo0 | SCENE= }}
{{STRUCTURE_2fo0| PDB=2fo0 | SCENE= }}
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'''Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase'''
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===Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase===
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==Overview==
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The tyrosine kinase c-Abl is inactivated by interactions made by its SH3 and SH2 domains with the distal surface of the kinase domain. We present a crystal structure of a fragment of c-Abl which reveals that a critical N-terminal cap segment, not visualized in previous structures, buttresses the SH3-SH2 substructure in the autoinhibited state and locks it onto the distal surface of the kinase domain. Surprisingly, the N-terminal cap is phosphorylated on a serine residue that interacts with the connector between the SH3 and SH2 domains. Small-angle X-ray scattering (SAXS) analysis shows that a mutated form of c-Abl, in which the N-terminal cap and two other key contacts in the autoinhibited state are deleted, exists in an extended array of the SH3, SH2, and kinase domains. This alternative conformation of Abl is likely to prolong the active state of the kinase by preventing it from returning to the autoinhibited state.
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The line below this paragraph, {{ABSTRACT_PUBMED_16543148}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16543148 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16543148}}
==About this Structure==
==About this Structure==
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[[Category: Phosphoserine]]
[[Category: Phosphoserine]]
[[Category: Sh3-sh2 clamp]]
[[Category: Sh3-sh2 clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:07:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:26:10 2008''

Revision as of 13:26, 29 July 2008

Image:2fo0.png

Template:STRUCTURE 2fo0

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

Template:ABSTRACT PUBMED 16543148

About this Structure

2FO0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase., Nagar B, Hantschel O, Seeliger M, Davies JM, Weis WI, Superti-Furga G, Kuriyan J, Mol Cell. 2006 Mar 17;21(6):787-98. PMID:16543148

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