2fon

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[[Image:2fon.gif|left|200px]]
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{{STRUCTURE_2fon| PDB=2fon | SCENE= }}
{{STRUCTURE_2fon| PDB=2fon | SCENE= }}
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'''X-ray crystal structure of LeACX1, an acyl-CoA oxidase from Lycopersicon esculentum (tomato)'''
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===X-ray crystal structure of LeACX1, an acyl-CoA oxidase from Lycopersicon esculentum (tomato)===
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==Overview==
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The flavoenzyme acyl-CoA oxidase (ACX) catalyzes the first committed step in beta-oxidation and is required for the biosynthesis of jasmonic acid, a signaling molecule involved in plant defense. Recently, a mutant in tomato was identified that is deficient in jasmonic acid production and compromised in its wound response. This results from a single point mutation in acx1, which causes the conserved residue Thr138 to be substituted by isoleucine. To understand the structural basis for this mutation, the crystal structure of LeACX1 was determined to 2.74 Angstrom resolution by molecular replacement. Unexpectedly, an unusual packing arrangement was observed in which three monomers of LeACX1 are present in the asymmetric unit. Although the tertiary structure of LeACX1 is essentially similar to the previously determined structures of ACX enzymes, the packing within the unit cells is distinctly different.
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The line below this paragraph, {{ABSTRACT_PUBMED_16699197}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16699197 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16699197}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Peroxisomal beta-oxidation]]
[[Category: Peroxisomal beta-oxidation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:08:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:50:10 2008''

Revision as of 09:50, 27 July 2008

Image:2fon.png

Template:STRUCTURE 2fon

X-ray crystal structure of LeACX1, an acyl-CoA oxidase from Lycopersicon esculentum (tomato)

Template:ABSTRACT PUBMED 16699197

About this Structure

2FON is a Single protein structure of sequence from Solanum lycopersicum. Full crystallographic information is available from OCA.

Reference

Structure determination and analysis of acyl-CoA oxidase (ACX1) from tomato., Powers RA, Rife CL, Schilmiller AL, Howe GA, Garavito RM, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):683-6. Epub 2006, May 12. PMID:16699197

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