2foy

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{{STRUCTURE_2foy| PDB=2foy | SCENE= }}
{{STRUCTURE_2foy| PDB=2foy | SCENE= }}
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'''Human Carbonic Anhydrase I complexed with a two-prong inhibitor'''
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===Human Carbonic Anhydrase I complexed with a two-prong inhibitor===
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==Overview==
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The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases.
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(as it appears on PubMed at http://www.pubmed.gov), where 16506782 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16506782}}
==About this Structure==
==About this Structure==
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[[Category: Lyase]]
[[Category: Lyase]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:09:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:24:33 2008''

Revision as of 05:24, 29 July 2008

Image:2foy.png

Template:STRUCTURE 2foy

Human Carbonic Anhydrase I complexed with a two-prong inhibitor

Template:ABSTRACT PUBMED 16506782

About this Structure

2FOY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity., Jude KM, Banerjee AL, Haldar MK, Manokaran S, Roy B, Mallik S, Srivastava DK, Christianson DW, J Am Chem Soc. 2006 Mar 8;128(9):3011-8. PMID:16506782

Page seeded by OCA on Tue Jul 29 08:24:33 2008

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