2fqm

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{{STRUCTURE_2fqm| PDB=2fqm | SCENE= }}
{{STRUCTURE_2fqm| PDB=2fqm | SCENE= }}
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'''Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus'''
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===Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus===
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==Overview==
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In the replication cycle of nonsegmented negative-strand RNA viruses, the viral RNA-dependent RNA polymerase (L) recognizes a nucleoprotein (N)-enwrapped RNA template during the RNA polymerase reaction. The viral phosphoprotein (P) is a polymerase cofactor essential for this recognition. We report here the 2.3-angstroms-resolution crystal structure of the central domain (residues 107 to 177) of P from vesicular stomatitis virus. The fold of this domain consists of a beta hairpin, an alpha helix, and another beta hairpin. The alpha helix provides the stabilizing force for forming a homodimer, while the two beta hairpins add additional stabilization by forming a four-stranded beta sheet through domain swapping between two molecules. This central dimer positions the N- and C-terminal domains of P to interact with the N and L proteins, allowing the L protein to specifically recognize the nucleocapsid-RNA template and to progress along the template while concomitantly assembling N with nascent RNA. The interdimer interactions observed in the noncrystallographic packing may offer insight into the mechanism of the RNA polymerase processive reaction along the viral nucleocapsid-RNA template.
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(as it appears on PubMed at http://www.pubmed.gov), where 16501089 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16501089}}
==About this Structure==
==About this Structure==
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[[Category: Polymerase]]
[[Category: Polymerase]]
[[Category: Replication]]
[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:12:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:33:44 2008''

Revision as of 12:33, 27 July 2008

Image:2fqm.png

Template:STRUCTURE 2fqm

Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus

Template:ABSTRACT PUBMED 16501089

About this Structure

2FQM is a Single protein structure of sequence from Vesicular stomatitis indiana virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus., Ding H, Green TJ, Lu S, Luo M, J Virol. 2006 Mar;80(6):2808-14. PMID:16501089

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