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2fqn

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{{STRUCTURE_2fqn| PDB=2fqn | SCENE= }}
{{STRUCTURE_2fqn| PDB=2fqn | SCENE= }}
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'''Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site'''
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===Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site===
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==Overview==
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The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493.
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(as it appears on PubMed at http://www.pubmed.gov), where 16452297 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16452297}}
==About this Structure==
==About this Structure==
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[[Category: Rna duplex]]
[[Category: Rna duplex]]
[[Category: Rrna]]
[[Category: Rrna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:12:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:32:09 2008''

Revision as of 22:32, 28 July 2008

Image:2fqn.png

Template:STRUCTURE 2fqn

Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site

Template:ABSTRACT PUBMED 16452297

About this Structure

Full crystallographic information is available from OCA.

Reference

Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site., Kondo J, Urzhumtsev A, Westhof E, Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:16452297

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