2frl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2frl.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2frl.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2frl| PDB=2frl | SCENE= }}
{{STRUCTURE_2frl| PDB=2frl | SCENE= }}
-
'''Solution structure of the helix II template boundary element from Tetrahymena telomerase RNA'''
+
===Solution structure of the helix II template boundary element from Tetrahymena telomerase RNA===
-
==Overview==
+
<!--
-
Telomere addition by telomerase requires an internal templating sequence located in the RNA subunit of telomerase. The correct boundary definition of this template sequence is essential for the proper addition of the nucleotide repeats. Incorporation of incorrect telomeric repeats onto the ends of chromosomes has been shown to induce chromosomal instability in ciliate, yeast and human cells. A 5' template boundary defining element (TBE) has been identified in human, yeast and ciliate telomerase RNAs. Here, we report the solution structure of the TBE element (helix II) from Tetrahymena thermophila telomerase RNA. Our results indicate that helix II and its capping pentaloop form a well-defined structure including unpaired, stacked adenine nucleotides in the stem and an unusual syn adenine nucleotide in the loop. A comparison of the T.thermophila helix II pentaloop with a pentaloop of the same sequence found in the 23S rRNA of the Haloarcula marismortui ribosome suggests possible RNA and/or protein interactions for the helix II loop within the Tetrahymena telomerase holoenzyme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16452301}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16452301 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16452301}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRL OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRL OCA].
==Reference==
==Reference==
Line 27: Line 31:
[[Category: Rna hairpin]]
[[Category: Rna hairpin]]
[[Category: Syn adenine]]
[[Category: Syn adenine]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:14:02 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:02:02 2008''

Revision as of 01:02, 28 July 2008

Image:2frl.png

Template:STRUCTURE 2frl

Solution structure of the helix II template boundary element from Tetrahymena telomerase RNA

Template:ABSTRACT PUBMED 16452301

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element., Richards RJ, Theimer CA, Finger LD, Feigon J, Nucleic Acids Res. 2006 Feb 1;34(3):816-25. Print 2006. PMID:16452301

Page seeded by OCA on Mon Jul 28 04:02:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2frl"
Personal tools