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2mhu
From Proteopedia
(New page: 200px<br /> <applet load="2mhu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2mhu" /> '''THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [1...) |
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'''THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY'''<br /> | '''THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2MHU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CD as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2MHU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CD:'>CD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: metallothionein]] | [[Category: metallothionein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:38:18 2008'' |
Revision as of 15:38, 15 February 2008
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THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Overview
The three-dimensional structure of human [113Cd7]metallothionein-2 was, determined by nuclear magnetic resonance spectroscopy in solution., Sequence-specific 1H resonance assignments were obtained using the, sequential assignment method. The input for the structure calculations, consisted of the metal-cysteine co-ordinative bonds identified with, heteronuclear correlation spectroscopy, 1H-1H distance constraints from, nuclear Overhauser enhancement spectroscopy, and spin-spin coupling, constants 3JHN alpha and 3J alpha beta. The molecule consists of two, domains, the beta-domain including amino acid residues 1 to 30 and three, metal ions, and the alpha-domain including residues 31 to 61 and four, metal ions. The nuclear magnetic resonance data present no evidence for a, preferred relative orientation of the two domains. The, polypeptide-to-metal co-ordinative bonds in human metallothionein-2 are, identical to those in the previously determined solution structures of rat, metallothionein-2 and rabbit metallothionein-2a, and the polypeptide, conformations in the three proteins are also closely similar.
About this Structure
2MHU is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy., Messerle BA, Schaffer A, Vasak M, Kagi JH, Wuthrich K, J Mol Biol. 1990 Aug 5;214(3):765-79. PMID:2388267
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