2fto

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[[Image:2fto.gif|left|200px]]
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{{Seed}}
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[[Image:2fto.png|left|200px]]
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{{STRUCTURE_2fto| PDB=2fto | SCENE= }}
{{STRUCTURE_2fto| PDB=2fto | SCENE= }}
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'''Y94F mutant of thymidylate synthase bound to thymidine-5'-phosphate and 10-propargyl-5,8-dideazafolid acid'''
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===Y94F mutant of thymidylate synthase bound to thymidine-5'-phosphate and 10-propargyl-5,8-dideazafolid acid===
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==Overview==
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Tyr94 of Escherichia coli thymidylate synthase is thought to be involved, either directly or by activation of a water molecule, in the abstraction of a proton from C5 of the 2'-deoxyuridine 5'-monophosphate (dUMP) substrate. Mutation of Tyr94 leads to a 400-fold loss in catalytic activity. The structure of the Y94F mutant has been determined in the native state and as a ternary complex with thymidine 5'-monophosphate (dTMP) and 10-propargyl 5,8-dideazafolate (PDDF). There are no structural changes ascribable to the mutation other than loss of a water molecule hydrogen bonded to the tyrosine OH, which is consistent with a catalytic role for the phenolic OH.
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(as it appears on PubMed at http://www.pubmed.gov), where 16946460 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16946460}}
==About this Structure==
==About this Structure==
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[[Category: Roberts, S A.]]
[[Category: Roberts, S A.]]
[[Category: Methyltransferase]]
[[Category: Methyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:17:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:53:30 2008''

Revision as of 15:53, 27 July 2008

Image:2fto.png

Template:STRUCTURE 2fto

Y94F mutant of thymidylate synthase bound to thymidine-5'-phosphate and 10-propargyl-5,8-dideazafolid acid

Template:ABSTRACT PUBMED 16946460

About this Structure

2FTO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the Y94F mutant of Escherichia coli thymidylate synthase., Roberts SA, Hyatt DC, Honts JE, Changchien L, Maley GF, Maley F, Montfort WR, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt, 9):840-3. Epub 2006 Aug 18. PMID:16946460

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