2fv4

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[[Image:2fv4.gif|left|200px]]
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{{STRUCTURE_2fv4| PDB=2fv4 | SCENE= }}
{{STRUCTURE_2fv4| PDB=2fv4 | SCENE= }}
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'''NMR solution structure of the yeast kinetochore Spc24/Spc25 globular domain'''
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===NMR solution structure of the yeast kinetochore Spc24/Spc25 globular domain===
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==Overview==
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The Ndc80 complex, a kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis. It is an approximately 570 A long, rod-shaped assembly of four proteins--Ndc80p (Hec1), Nuf2p, Spc24p, and Spc25p--with globular regions at either end of a central shaft. The complex bridges from the centromere-proximal inner kinetochore layer at its Spc24/Spc25 globular end to the microtubule binding outer kinetochore layer at its Ndc80/Nuf2 globular end. We report the atomic structures of the Spc24/Spc25 globular domain, determined both by X-ray crystallography at 1.9 A resolution and by NMR. Spc24 and Spc25 fold tightly together into a single globular entity with pseudo-2-fold symmetry. Conserved residues line a common hydrophobic core and the bottom of a cleft, indicating that the functional orthologs from other eukaryotes will have the same structure and suggesting a docking site for components of the inner kinetochore.
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{{ABSTRACT_PUBMED_16765893}}
==About this Structure==
==About this Structure==
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2FV4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV4 OCA].
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2FV4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV4 OCA].
==Reference==
==Reference==
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[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
[[Category: Complex]]
[[Category: Complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:20:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:56:45 2008''

Revision as of 02:56, 29 July 2008

Image:2fv4.png

Template:STRUCTURE 2fv4

NMR solution structure of the yeast kinetochore Spc24/Spc25 globular domain

Template:ABSTRACT PUBMED 16765893

About this Structure

2FV4 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain., Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC, Structure. 2006 Jun;14(6):1003-9. PMID:16765893

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