2fvn

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[[Image:2fvn.jpg|left|200px]]
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{{Seed}}
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[[Image:2fvn.png|left|200px]]
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{{STRUCTURE_2fvn| PDB=2fvn | SCENE= }}
{{STRUCTURE_2fvn| PDB=2fvn | SCENE= }}
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'''The fibrillar tip complex of the Afa/Dr adhesins from pathogen E. coli displays synergistic binding to 5 1 and v 3 integrins'''
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===The fibrillar tip complex of the Afa/Dr adhesins from pathogen E. coli displays synergistic binding to 5 1 and v 3 integrins===
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==Overview==
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Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_16965519}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16965519 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16965519}}
==About this Structure==
==About this Structure==
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2FVN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVN OCA].
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2FVN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVN OCA].
==Reference==
==Reference==
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[[Category: Fibrillar]]
[[Category: Fibrillar]]
[[Category: Integrin-binding]]
[[Category: Integrin-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:21:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:21:06 2008''

Revision as of 16:21, 28 July 2008

Image:2fvn.png

Template:STRUCTURE 2fvn

The fibrillar tip complex of the Afa/Dr adhesins from pathogen E. coli displays synergistic binding to 5 1 and v 3 integrins

Template:ABSTRACT PUBMED 16965519

About this Structure

2FVN is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

The solution structure of the invasive tip complex from Afa/Dr fibrils., Cota E, Jones C, Simpson P, Altroff H, Anderson KL, du Merle L, Guignot J, Servin A, Le Bouguenec C, Mardon H, Matthews S, Mol Microbiol. 2006 Oct;62(2):356-66. Epub 2006 Sep 8. PMID:16965519

Page seeded by OCA on Mon Jul 28 19:21:06 2008

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