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2fxu

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[[Image:2fxu.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2fxu| PDB=2fxu | SCENE= }}
{{STRUCTURE_2fxu| PDB=2fxu | SCENE= }}
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'''X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.'''
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===X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.===
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==Overview==
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Bistramide A is a highly potent antiproliferative marine natural product from Lissoclinum bistratum. We have previously established actin as the primary cellular receptor of bistramide A. We report herein the X-ray structure of bistramide A bound to monomeric actin at a resolution of 1.35 A. The most notable aspect of the bistramide A-actin structure is an extensive hydrogen-bonding network established upon a deep penetration of the central segment of bistramide A into the actin-binding cleft between subdomains 1 and 3. The structure presents the first insight into the observed ability of bistramide A to modulate G-actin polymerization. The structural information combined with our ability to chemically modify the bistramide framework provides the basis for rational development of a series of new synthetic analogues as useful probes for studying actin cytoskeleton and as potential therapeutic leads.
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(as it appears on PubMed at http://www.pubmed.gov), where 16551075 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16551075}}
==About this Structure==
==About this Structure==
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[[Category: Tereshko, V.]]
[[Category: Tereshko, V.]]
[[Category: Actin complexed to bistramide some]]
[[Category: Actin complexed to bistramide some]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:25:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:05:51 2008''

Revision as of 18:05, 28 July 2008

Image:2fxu.png

Template:STRUCTURE 2fxu

X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.

Template:ABSTRACT PUBMED 16551075

About this Structure

2FXU is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structure of bistramide A-actin complex at a 1.35 angstroms resolution., Rizvi SA, Tereshko V, Kossiakoff AA, Kozmin SA, J Am Chem Soc. 2006 Mar 29;128(12):3882-3. PMID:16551075

Page seeded by OCA on Mon Jul 28 21:05:51 2008

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