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2fz3

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{{STRUCTURE_2fz3| PDB=2fz3 | SCENE= }}
{{STRUCTURE_2fz3| PDB=2fz3 | SCENE= }}
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'''The role of T cell receptor alpha genes in directing human MHC restriction'''
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===The role of T cell receptor alpha genes in directing human MHC restriction===
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==Overview==
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The underlying generic properties of alphabeta TCRs that control MHC restriction remain largely unresolved. To investigate MHC restriction, we have examined the CTL response to a viral epitope that binds promiscuously to two human leukocyte Ags (HLAs) that differ by a single amino acid at position 156. Individuals expressing either HLA-B*3501 (156Leucine) or HLA-B*3508 (156Arginine) showed a potent CTL response to the 407HPVGEADYFEY417 epitope from EBV. Interestingly, the response was characterized by highly restricted TCR beta-chain usage in both HLA-B*3501+ and HLA-B*3508+ individuals; however, this conserved TRBV9+ beta-chain was associated with distinct TCR alpha-chains depending upon the HLA-B*35 allele expressed by the virus-exposed host. Functional assays confirmed that TCR alpha-chain usage determined the HLA restriction of the CTLs. Structural studies revealed significant differences in the mobility of the peptide when bound to HLA-B*3501 or HLA-B*3508. In HLA-B*3501, the bulged section of the peptide was disordered, whereas in HLA-B*3508 the bulged epitope adopted an ordered conformation. Collectively, these data demonstrate not only that mobile MHC-bound peptides can be highly immunogenic but can also stimulate an extremely biased TCR repertoire. In addition, TCR alpha-chain usage is shown to play a critical role in controlling MHC restriction between closely related allomorphs.
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(as it appears on PubMed at http://www.pubmed.gov), where 17082594 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17082594}}
==About this Structure==
==About this Structure==
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[[Category: Ig domain]]
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[[Category: Mhc]]
[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:28:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:46:16 2008''

Revision as of 01:46, 28 July 2008

Image:2fz3.png

Template:STRUCTURE 2fz3

The role of T cell receptor alpha genes in directing human MHC restriction

Template:ABSTRACT PUBMED 17082594

About this Structure

2FZ3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope., Miles JJ, Borg NA, Brennan RM, Tynan FE, Kjer-Nielsen L, Silins SL, Bell MJ, Burrows JM, McCluskey J, Rossjohn J, Burrows SR, J Immunol. 2006 Nov 15;177(10):6804-14. PMID:17082594

Page seeded by OCA on Mon Jul 28 04:46:16 2008

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