2g12

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{{STRUCTURE_2g12| PDB=2g12 | SCENE= }}
{{STRUCTURE_2g12| PDB=2g12 | SCENE= }}
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'''Photolyzed CO L29F Myoglobin: 316ns'''
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===Photolyzed CO L29F Myoglobin: 316ns===
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==Overview==
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Picosecond time-resolved crystallography was used to follow the dissociation of carbon monoxide from the heme pocket of a mutant sperm whale myoglobin and the resultant conformational changes. Electron-density maps have previously been created at various time points and used to describe amino-acid side-chain and carbon monoxide movements. In this work, difference refinement was employed to generate atomic coordinates at each time point in order to create a more explicit quantitative representation of the photo-dissociation process. After photolysis the carbon monoxide moves to a docking site, causing rearrangements in the heme-pocket residues, the coordinate changes of which can be plotted as a function of time. These include rotations of the heme-pocket phenylalanine concomitant with movement of the distal histidine toward the solvent, potentially allowing carbon monoxide movement in and out of the protein and proximal displacement of the heme iron. The degree of relaxation toward the intermediate and deoxy states was probed by analysis of the coordinate movements in the time-resolved models, revealing a non-linear progression toward the unbound state with coordinate movements that begin in the heme-pocket area and then propagate throughout the rest of the protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 16790933 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16790933}}
==About this Structure==
==About this Structure==
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[[Category: Structure-function relationship]]
[[Category: Structure-function relationship]]
[[Category: Time-resolved crystallography]]
[[Category: Time-resolved crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:34:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:35:19 2008''

Revision as of 09:35, 10 July 2008

Image:2g12.png

Template:STRUCTURE 2g12

Photolyzed CO L29F Myoglobin: 316ns

Template:ABSTRACT PUBMED 16790933

About this Structure

2G12 is a Single protein structure of sequence from Physeter catodon. Full crystallographic information is available from OCA.

Reference

Time-dependent atomic coordinates for the dissociation of carbon monoxide from myoglobin., Aranda R 4th, Levin EJ, Schotte F, Anfinrud PA, Phillips GN Jr, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):776-83. Epub 2006, Jun 20. PMID:16790933

Page seeded by OCA on Thu Jul 10 12:35:19 2008

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