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2g23

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[[Image:2g23.gif|left|200px]]
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{{STRUCTURE_2g23| PDB=2g23 | SCENE= }}
{{STRUCTURE_2g23| PDB=2g23 | SCENE= }}
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'''The crystal structure of hexameric phenoxazinone synthase'''
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===The crystal structure of hexameric phenoxazinone synthase===
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==Overview==
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The multicopper oxidase phenoxazinone synthase (PHS) catalyzes the penultimate step in the biosynthesis of the antibiotic actinomycin D by Streptomyces antibioticus. PHS exists in two oligomeric forms: a dimeric form and a hexameric form, with older actinomycin-producing cultures containing predominately the hexameric form. The structure of hexameric PHS has been determined using X-ray diffraction to a resolution limit of 2.30 A and is found to contain several unexpected and distinctive features. The structure forms a hexameric ring that is centered on a pseudo 6-fold axis and has an outer diameter of 185 A with a large central cavity that has a diameter of 50 A. This hexameric structure is stabilized by a long loop connecting two domains; bound to this long loop is a fifth copper atom that is present as a type 2 copper. This copper atom is not present in any other multicopper oxidase, and its presence appears to stabilize the hexameric structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 16584173 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16584173}}
==About this Structure==
==About this Structure==
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[[Category: Metalloprotein]]
[[Category: Metalloprotein]]
[[Category: Multicopper oxidase]]
[[Category: Multicopper oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:36:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:00:57 2008''

Revision as of 01:01, 28 July 2008

Image:2g23.png

Template:STRUCTURE 2g23

The crystal structure of hexameric phenoxazinone synthase

Template:ABSTRACT PUBMED 16584173

About this Structure

2G23 is a Single protein structure of sequence from Streptomyces antibioticus. Full crystallographic information is available from OCA.

Reference

Structure of phenoxazinone synthase from Streptomyces antibioticus reveals a new type 2 copper center., Smith AW, Camara-Artigas A, Wang M, Allen JP, Francisco WA, Biochemistry. 2006 Apr 11;45(14):4378-87. PMID:16584173

Page seeded by OCA on Mon Jul 28 04:00:57 2008

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