2g2q

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{{STRUCTURE_2g2q| PDB=2g2q | SCENE= }}
{{STRUCTURE_2g2q| PDB=2g2q | SCENE= }}
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'''The crystal structure of G4, the poxviral disulfide oxidoreductase essential for cytoplasmic disulfide bond formation'''
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===The crystal structure of G4, the poxviral disulfide oxidoreductase essential for cytoplasmic disulfide bond formation===
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==Overview==
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The possibility of the release of smallpox virus into a predominantly nonimmunized population highlights the importance of understanding poxvirus biology. Poxviruses encode a conserved pathway that is required to oxidize disulfide bonds in nascent viral proteins that fold in the reducing environment of the eukaryotic host cytoplasm. We present the structure of the last enzyme of the vaccinia virus pathway, G4, which is almost identical in smallpox virus. G4 catalyzes the formation of disulfide bonds in proteins that are critical for virus maturation and host cell infection. G4 contains a thioredoxin fold and a Cys-X-X-Cys active site. In solution, G4 monomers and dimers are observed. In the crystal, G4 is found as a dimer that buries 4,500 A(2) in the interface and occludes the active site, which could protect the reactive disulfide from reduction in the cytoplasm. The structure serves as a model for drug design targeting viral disulfide bond formation.
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The line below this paragraph, {{ABSTRACT_PUBMED_16840349}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16840349 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16840349}}
==About this Structure==
==About this Structure==
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[[Category: Thioredoxin-fold]]
[[Category: Thioredoxin-fold]]
[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:37:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:30:29 2008''

Revision as of 18:30, 28 July 2008

Image:2g2q.png

Template:STRUCTURE 2g2q

The crystal structure of G4, the poxviral disulfide oxidoreductase essential for cytoplasmic disulfide bond formation

Template:ABSTRACT PUBMED 16840349

About this Structure

2G2Q is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

The structure of G4, the poxvirus disulfide oxidoreductase essential for virus maturation and infectivity., Su HP, Lin DY, Garboczi DN, J Virol. 2006 Aug;80(15):7706-13. PMID:16840349

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