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2g34

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{{STRUCTURE_2g34| PDB=2g34 | SCENE= }}
{{STRUCTURE_2g34| PDB=2g34 | SCENE= }}
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'''Human hepatitis B virus T=4 capsid strain adyw complexed with assembly effector HAP1'''
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===Human hepatitis B virus T=4 capsid strain adyw complexed with assembly effector HAP1===
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==Overview==
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Hepatitis B virus (HBV) is a leading cause of liver disease and hepatocellular carcinoma; over 400 million people are chronically infected with HBV. Specific anti-HBV treatments, like most antivirals, target enzymes that are similar to host proteins. Virus capsid protein has no human homolog, making its assembly a promising but undeveloped therapeutic target. HAP1 [methyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(pyridin-2-yl)-1,4-dihydropyrimidin e-5-carboxylate], a heteroaryldihydropyrimidine, is a potent HBV capsid assembly activator and misdirector. Knowledge of the structural basis for this activity would directly benefit the development of capsid-targeting therapeutic strategies. This report details the crystal structures of icosahedral HBV capsids with and without HAP1. We show that HAP1 leads to global structural changes by movements of subunits as connected rigid bodies. The observed movements cause the fivefold vertices to protrude from the liganded capsid, the threefold vertices to open, and the quasi-sixfold vertices to flatten, explaining the effects of HAP1 on assembled capsids and on the assembly process. We have identified a likely HAP1-binding site that bridges elements of secondary structure within a capsid-bound monomer, offering explanation for assembly activation. This site also interferes with interactions between capsid proteins, leading to quaternary changes and presumably assembly misdirection. These results demonstrate the plasticity of HBV capsids and the molecular basis for a tenable antiviral strategy.
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{{ABSTRACT_PUBMED_16943288}}
==About this Structure==
==About this Structure==
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[[Category: Icosohedral]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:03:21 2008''

Revision as of 00:03, 29 July 2008

Image:2g34.png

Template:STRUCTURE 2g34

Human hepatitis B virus T=4 capsid strain adyw complexed with assembly effector HAP1

Template:ABSTRACT PUBMED 16943288

About this Structure

2G34 is a Single protein structure of sequence from Hepatitis b virus subtype adyw. Full crystallographic information is available from OCA.

Reference

Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1., Bourne CR, Finn MG, Zlotnick A, J Virol. 2006 Nov;80(22):11055-61. Epub 2006 Aug 30. PMID:16943288

Page seeded by OCA on Tue Jul 29 03:03:21 2008

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