2g43

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{{STRUCTURE_2g43| PDB=2g43 | SCENE= }}
{{STRUCTURE_2g43| PDB=2g43 | SCENE= }}
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'''Structure of the ZNF UBP domain from deubiquitinating enzyme isopeptidase T (IsoT)'''
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===Structure of the ZNF UBP domain from deubiquitinating enzyme isopeptidase T (IsoT)===
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==Overview==
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Ubiquitin binding proteins regulate the stability, function, and/or localization of ubiquitinated proteins. Here we report the crystal structures of the zinc-finger ubiquitin binding domain (ZnF UBP) from the deubiquitinating enzyme isopeptidase T (IsoT, or USP5) alone and in complex with ubiquitin. Unlike other ubiquitin binding domains, this domain contains a deep binding pocket where the C-terminal diglycine motif of ubiquitin is inserted, thus explaining the specificity of IsoT for an unmodified C terminus on the proximal subunit of polyubiquitin. Mutations in the domain demonstrate that it is required for optimal catalytic activation of IsoT. This domain is present in several other protein families, and the ZnF UBP domain from an E3 ligase also requires the C terminus of ubiquitin for binding. These data suggest that binding the ubiquitin C terminus may be necessary for the function of other proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 16564012 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16564012}}
==About this Structure==
==About this Structure==
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[[Category: Deubiquitinating enzyme]]
[[Category: Deubiquitinating enzyme]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:40:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:46:10 2008''

Revision as of 13:46, 27 July 2008

Image:2g43.png

Template:STRUCTURE 2g43

Structure of the ZNF UBP domain from deubiquitinating enzyme isopeptidase T (IsoT)

Template:ABSTRACT PUBMED 16564012

About this Structure

2G43 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin., Reyes-Turcu FE, Horton JR, Mullally JE, Heroux A, Cheng X, Wilkinson KD, Cell. 2006 Mar 24;124(6):1197-208. PMID:16564012

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