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2g5q

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{{STRUCTURE_2g5q| PDB=2g5q | SCENE= }}
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'''Crystal structures of the bacterial ribosomal decoding site complexed with amikacin.'''
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===Crystal structures of the bacterial ribosomal decoding site complexed with amikacin.===
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==Overview==
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Amikacin is the 4,6-linked aminoglycoside modified at position N1 of the 2-deoxystreptamine ring (ring II) by the L-haba group. In the present study, the crystal structure of a complex between oligonucleotide containing the bacterial ribosomal A site and amikacin has been solved at 2.7 A resolution. Amikacin specifically binds to the A site in practically the same way as its parent compound kanamycin. In addition, the L-haba group interacts with the upper side of the A site through two direct contacts, O2*...H-N4(C1496) and N4*-H...O6(G1497). The present crystal structure shows how the introduction of the L-haba group on ring II of aminoglycoside is an effective mutation for obtaining a higher affinity to the bacterial A site.
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(as it appears on PubMed at http://www.pubmed.gov), where 16806634 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16806634}}
==About this Structure==
==About this Structure==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: X-ray analysis]]
[[Category: X-ray analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:43:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:12:20 2008''

Revision as of 13:12, 29 July 2008

Image:2g5q.png

Template:STRUCTURE 2g5q

Crystal structures of the bacterial ribosomal decoding site complexed with amikacin.

Template:ABSTRACT PUBMED 16806634

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group., Kondo J, Francois B, Russell RJ, Murray JB, Westhof E, Biochimie. 2006 Aug;88(8):1027-31. Epub 2006 Jun 13. PMID:16806634

Page seeded by OCA on Tue Jul 29 16:12:20 2008

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