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2g7c

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[[Image:2g7c.gif|left|200px]]
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{{STRUCTURE_2g7c| PDB=2g7c | SCENE= }}
{{STRUCTURE_2g7c| PDB=2g7c | SCENE= }}
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'''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''
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===Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc===
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==Overview==
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Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.
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(as it appears on PubMed at http://www.pubmed.gov), where 16622409 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16622409}}
==About this Structure==
==About this Structure==
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[[Category: Linear b trisaccharide]]
[[Category: Linear b trisaccharide]]
[[Category: Protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:46:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:39:51 2008''

Revision as of 09:39, 28 July 2008

Image:2g7c.png

Template:STRUCTURE 2g7c

Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc

Template:ABSTRACT PUBMED 16622409

About this Structure

2G7C is a Single protein structure of sequence from Clostridium difficile. Full crystallographic information is available from OCA.

Reference

Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:16622409

Page seeded by OCA on Mon Jul 28 12:39:51 2008

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