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2g9c

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{{STRUCTURE_2g9c| PDB=2g9c | SCENE= }}
{{STRUCTURE_2g9c| PDB=2g9c | SCENE= }}
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'''Modified pyrimidines Specifically bind the purine riboswitch'''
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===Modified pyrimidines Specifically bind the purine riboswitch===
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==Overview==
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The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
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(as it appears on PubMed at http://www.pubmed.gov), where 17076468 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17076468}}
==About this Structure==
==About this Structure==
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[[Category: Rna-ligand complex]]
[[Category: Rna-ligand complex]]
[[Category: Triaminopyrimidine]]
[[Category: Triaminopyrimidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:50:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:36:00 2008''

Revision as of 17:36, 27 July 2008

Image:2g9c.png

Template:STRUCTURE 2g9c

Modified pyrimidines Specifically bind the purine riboswitch

Template:ABSTRACT PUBMED 17076468

About this Structure

Full crystallographic information is available from OCA.

Reference

Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468

Page seeded by OCA on Sun Jul 27 20:36:00 2008

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