2g9t

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{{STRUCTURE_2g9t| PDB=2g9t | SCENE= }}
{{STRUCTURE_2g9t| PDB=2g9t | SCENE= }}
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'''Crystal structure of the SARS coronavirus nsp10 at 2.1A'''
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===Crystal structure of the SARS coronavirus nsp10 at 2.1A===
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==Overview==
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The severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural proteins nsp1 to nsp16 have been implicated by genetic analysis in the assembly of a functional replication/transcription complex. We report the crystal structure of nsp10 from SARS-CoV at 2.1-A resolution. The nsp10 structure has a novel fold, and 12 identical subunits assemble to form a unique spherical dodecameric architecture. Two zinc fingers have been identified from the nsp10 monomer structure with the sequence motifs C-(X)2-C-(X)5-H-(X)6-C and C-(X)2-C-(X)7-C-(X)-C. The nsp10 crystal structure is the first of a new class of zinc finger protein three-dimensional structures to be revealed experimentally. The zinc finger sequence motifs are conserved among all three coronavirus antigenic groups, implicating an essential function for nsp10 in all coronaviruses. Based on the structure, we propose that nsp10 is a transcription factor for coronavirus replication/transcription.
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{{ABSTRACT_PUBMED_16873247}}
==About this Structure==
==About this Structure==
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[[Category: Nsp10]]
[[Category: Nsp10]]
[[Category: Sar]]
[[Category: Sar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:51:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:34:50 2008''

Revision as of 16:34, 27 July 2008

Image:2g9t.png

Template:STRUCTURE 2g9t

Crystal structure of the SARS coronavirus nsp10 at 2.1A

Template:ABSTRACT PUBMED 16873247

About this Structure

2G9T is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10., Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z, J Virol. 2006 Aug;80(16):7902-8. PMID:16873247

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