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2gb8

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[[Image:2gb8.gif|left|200px]]
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{{STRUCTURE_2gb8| PDB=2gb8 | SCENE= }}
{{STRUCTURE_2gb8| PDB=2gb8 | SCENE= }}
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'''Solution structure of the complex between yeast iso-1-cytochrome c and yeast cytochrome c peroxidase'''
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===Solution structure of the complex between yeast iso-1-cytochrome c and yeast cytochrome c peroxidase===
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==Overview==
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The physiological complex of yeast cytochrome c peroxidase and iso-1-cytochrome c is a paradigm for biological electron transfer. Using paramagnetic NMR spectroscopy, we have determined the conformation of the protein complex in solution, which is shown to be very similar to that observed in the crystal structure [Pelletier H, Kraut J (1992) Science 258:1748-1755]. Our results support the view that this transient electron transfer complex is dynamic. The solution structure represents the dominant protein-protein orientation, which, according to our estimates, is occupied for &gt;70% of the lifetime of the complex, with the rest of the time spent in the dynamic encounter state. Based on the observed paramagnetic effects, we have delineated the conformational space sampled by the protein molecules during the dynamic part of the interaction, providing experimental support for the theoretical predictions of the classical Brownian dynamics study [Northrup SH, Boles JO, Reynolds JCL (1988) Science 241:67-70]. Our findings corroborate the dynamic behavior of this complex and offer an insight into the mechanism of the protein complex formation in solution.
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(as it appears on PubMed at http://www.pubmed.gov), where 17146057 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17146057}}
==About this Structure==
==About this Structure==
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2GB8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GB8 OCA].
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2GB8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GB8 OCA].
==Reference==
==Reference==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Transient complex]]
[[Category: Transient complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:54:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:31:16 2008''

Revision as of 03:31, 28 July 2008

Image:2gb8.png

Template:STRUCTURE 2gb8

Solution structure of the complex between yeast iso-1-cytochrome c and yeast cytochrome c peroxidase

Template:ABSTRACT PUBMED 17146057

About this Structure

2GB8 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Solution structure and dynamics of the complex between cytochrome c and cytochrome c peroxidase determined by paramagnetic NMR., Volkov AN, Worrall JA, Holtzmann E, Ubbink M, Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18945-50. Epub 2006 Dec 4. PMID:17146057

Page seeded by OCA on Mon Jul 28 06:31:16 2008

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