2gd3

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{{STRUCTURE_2gd3| PDB=2gd3 | SCENE= }}
{{STRUCTURE_2gd3| PDB=2gd3 | SCENE= }}
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'''NMR structure of S14G-humanin in 30% TFE solution'''
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===NMR structure of S14G-humanin in 30% TFE solution===
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==Overview==
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The NMR solution study of Ser14Gly-humanin (S14G-HN), a 1000-fold more potent derivative of humanin (HN), is reported. HN is 24-residue peptide that selectively suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults and offers hope for the development of a cure against AD. In aqueous solution the NMR data show that S14G-HN is a flexible peptide with turn-like structures in its conformational ensemble distributed over an extensive part of its sequence from Pro3 to Glu15. In the more lipophilic environment of 30% TFE, an alpha-helical structure spanning residues Phe6 to Thr13 is identified. Comparison of these findings to the NMR structure of the parent HN and to existing structure-function relationship literature data outlines the important for activity structural features for this class of neuroprotective peptides, and brings forth flexibility as an important characteristic that may facilitate interactions with functional counterparts of the neuroprotection pathway.
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The line below this paragraph, {{ABSTRACT_PUBMED_16945331}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16945331 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16945331}}
==About this Structure==
==About this Structure==
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2GD3 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GD3 OCA].
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2GD3 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GD3 OCA].
==Reference==
==Reference==
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease., Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M, Biochem Biophys Res Commun. 2006 Oct 20;349(2):634-42. Epub 2006 Aug 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16945331 16945331]
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease., Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M, Biochem Biophys Res Commun. 2006 Oct 20;349(2):634-42. Epub 2006 Aug 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16945331 16945331]
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Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity., Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M, Biochem Biophys Res Commun. 2005 Apr 1;329(1):152-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15721287 15721287]
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A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta., Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I, Proc Natl Acad Sci U S A. 2001 May 22;98(11):6336-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11371646 11371646]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Benaki, D.]]
[[Category: Benaki, D.]]
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: S14g-humanin]]
[[Category: S14g-humanin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:58:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:19:16 2008''

Revision as of 09:19, 27 July 2008

Image:2gd3.png

Template:STRUCTURE 2gd3

NMR structure of S14G-humanin in 30% TFE solution

Template:ABSTRACT PUBMED 16945331

About this Structure

2GD3 is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease., Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M, Biochem Biophys Res Commun. 2006 Oct 20;349(2):634-42. Epub 2006 Aug 23. PMID:16945331

Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity., Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M, Biochem Biophys Res Commun. 2005 Apr 1;329(1):152-60. PMID:15721287

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta., Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I, Proc Natl Acad Sci U S A. 2001 May 22;98(11):6336-41. PMID:11371646

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