1y1a

From Proteopedia

Revision as of 10:12, 30 October 2007

CRYSTAL STRUCTURE OF CALCIUM AND INTEGRIN BINDING PROTEIN

Overview

Calcium- and integrin-binding protein 1 (CIB1) is involved in the process, of platelet aggregation by binding the cytoplasmic tail of the alpha(IIb), subunit of the platelet-specific integrin alpha(Iib)beta(3). Although, poorly understood, it is widely believed that CIB1 acts as a global, signaling regulator because it is expressed in many tissues that do not, express integrin alpha(Iib)beta(3). We report the structure of human CIB1, to a resolution of 2.3 A, crystallized as a dimer. The dimer interface, includes an extensive hydrophobic patch in a crystal form with 80% solvent, content. Although the dimer form of CIB1 may not be physiologically, relevant, this intersub-unit surface is likely to be linked to alpha(IIb), binding and to the binding of other signaling partner proteins. The, ... [(full description)]

About this Structure

1Y1A is a [Single protein] structure of sequence from [Homo sapiens] with CA and GSH as [ligands]. Structure known Active Sites: CA1, CA2, CA3 and CA4. Full crystallographic information is available from [OCA].

Reference

The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions., Blamey CJ, Ceccarelli C, Naik UP, Bahnson BJ, Protein Sci. 2005 May;14(5):1214-21. PMID:15840829

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