2o71
From Proteopedia
(New page: 200px<br /> <applet load="2o71" size="450" color="white" frame="true" align="right" spinBox="true" caption="2o71, resolution 2.0Å" /> '''Crystal structure of...) |
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caption="2o71, resolution 2.0Å" /> | caption="2o71, resolution 2.0Å" /> | ||
'''Crystal structure of RAIDD DD'''<br /> | '''Crystal structure of RAIDD DD'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Caspase-2 is implicated in stress-induced apoptosis that acts as an | + | Caspase-2 is implicated in stress-induced apoptosis that acts as an upstream initiator of mitochondrial permeabilization. Recent studies have shown that caspase-2 activation requires a molecular complex known as the PIDDosome comprising the p53-inducible protein PIDD, the adapter protein RAIDD and caspase-2. RAIDD has an N-terminal caspase recruitment domain (CARD) that interacts with the CARD of caspase-2 and a C-terminal death domain (DD) that interacts with the DD in PIDD. As a first step towards elucidating the molecular mechanisms of caspase-2 activation, we report the crystal structure of RAIDD DD at 2.0 A resolution. The high-resolution structure reveals important features of RAIDD DD that may be important for DD folding and dynamics and for assembly of the PIDDosome. |
==About this Structure== | ==About this Structure== | ||
| - | 2O71 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2O71 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O71 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: raidd]] | [[Category: raidd]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:15:12 2008'' |
Revision as of 16:15, 21 February 2008
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Crystal structure of RAIDD DD
Overview
Caspase-2 is implicated in stress-induced apoptosis that acts as an upstream initiator of mitochondrial permeabilization. Recent studies have shown that caspase-2 activation requires a molecular complex known as the PIDDosome comprising the p53-inducible protein PIDD, the adapter protein RAIDD and caspase-2. RAIDD has an N-terminal caspase recruitment domain (CARD) that interacts with the CARD of caspase-2 and a C-terminal death domain (DD) that interacts with the DD in PIDD. As a first step towards elucidating the molecular mechanisms of caspase-2 activation, we report the crystal structure of RAIDD DD at 2.0 A resolution. The high-resolution structure reveals important features of RAIDD DD that may be important for DD folding and dynamics and for assembly of the PIDDosome.
About this Structure
2O71 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly., Park HH, Wu H, J Mol Biol. 2006 Mar 24;357(2):358-64. Epub 2006 Jan 11. PMID:16434054
Page seeded by OCA on Thu Feb 21 18:15:12 2008
Categories: Homo sapiens | Single protein | Park, H. | Wu, H. | Death domain | Raidd
