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2gfp

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[[Image:2gfp.gif|left|200px]]
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[[Image:2gfp.png|left|200px]]
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==Overview==
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{{ABSTRACT_16675700}}
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EmrD is a multidrug transporter from the Major Facilitator Superfamily that expels amphipathic compounds across the inner membrane of Escherichia coli. Here, we report the x-ray structure of EmrD determined to a resolution of 3.5 angstroms. The structure reveals an interior that is composed mostly of hydrophobic residues, which is consistent with its role transporting amphipathic molecules. Two long loops extend into the inner leaflet side of the cell membrane. This region can serve to recognize and bind substrate directly from the lipid bilayer. We propose that multisubstrate specificity, binding, and transport are facilitated by these loop regions and the internal cavity.
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==About this Structure==
==About this Structure==
2GFP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFP OCA].
2GFP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFP OCA].
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==Reference==
 
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Structure of the multidrug transporter EmrD from Escherichia coli., Yin Y, He X, Szewczyk P, Nguyen T, Chang G, Science. 2006 May 5;312(5774):741-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16675700 16675700]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Multidrug transporter]]
[[Category: Multidrug transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:03:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:17:10 2008''

Revision as of 15:17, 26 June 2008

Image:2gfp.png

Template:STRUCTURE 2gfp

Structure of the Multidrug Transporter EmrD from Escherichia coli


Template:ABSTRACT 16675700

About this Structure

2GFP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:17:10 2008

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