2ggc

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{{STRUCTURE_2ggc| PDB=2ggc | SCENE= }}
{{STRUCTURE_2ggc| PDB=2ggc | SCENE= }}
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'''Novel bacterial methionine aminopeptidase inhibitors'''
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===Novel bacterial methionine aminopeptidase inhibitors===
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==Overview==
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In this article we describe the application of structural biology methods to the discovery of novel potent inhibitors of methionine aminopeptidases. These enzymes are employed by the cells to cleave the N-terminal methionine from nascent peptides and proteins. As this is one of the critical steps in protein maturation, it is very likely that inhibitors of these enzymes may prove useful as novel antibacterial agents. Involvement of crystallography at the very early stages of the inhibitor design process resulted in serendipitous discovery of a new inhibitor class, the pyrazole-diamines. Atomic-resolution structures of several inhibitors bound to the enzyme illuminate a new mode of inhibitor binding.
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==About this Structure==
==About this Structure==
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[[Category: Methionine amino peptidase]]
[[Category: Methionine amino peptidase]]
[[Category: Pita-bread fold]]
[[Category: Pita-bread fold]]
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Revision as of 07:05, 29 July 2008

Image:2ggc.png

Template:STRUCTURE 2ggc

Novel bacterial methionine aminopeptidase inhibitors

Template:ABSTRACT PUBMED 17120228

About this Structure

2GGC is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors., Evdokimov AG, Pokross M, Walter RL, Mekel M, Barnett BL, Amburgey J, Seibel WL, Soper SJ, Djung JF, Fairweather N, Diven C, Rastogi V, Grinius L, Klanke C, Siehnel R, Twinem T, Andrews R, Curnow A, Proteins. 2007 Feb 15;66(3):538-46. PMID:17120228

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